CPT® code 84481 is used to report a laboratory test measuring thyroid peroxidase (TPO) antibodies in the blood. TPO antibodies are markers of autoimmune thyroid disease, including Hashimoto’s thyroiditis and Graves’ disease. Testing for TPO antibodies is an important tool for diagnosing and monitoring autoimmune thyroid disorders, especially when patients present with abnormal thyroid function or clinical symptoms.
When to Use CPT® Code 84481
- When evaluating patients with suspected autoimmune thyroid disease.
- For patients with abnormal TSH or thyroid hormone levels to determine the cause.
- To monitor disease progression or response to therapy in autoimmune thyroid disorders.
- When patients present with symptoms such as fatigue, weight changes, or goiter.
Billing Requirements
- Report per test performed.
- Documentation must include the clinical indication for TPO antibody testing.
- May be performed alongside other thyroid tests (e.g., TSH, free T4), billed with their respective CPT® codes.
- Ensure appropriate ICD-10 codes are included for medical necessity.
Common Clinical Scenarios
- A primary care provider orders a TPO antibody test after a patient’s TSH is abnormal during routine screening.
- An endocrinologist monitors a patient with Hashimoto’s thyroiditis for autoimmune progression.
- A patient with a family history of thyroid disease undergoes testing for early detection of autoimmune activity.
Streamline Autoimmune Thyroid Testing with OptiMantra
Accurate billing and documentation for CPT® 84481 are essential for compliance and proper reimbursement. OptiMantra’s EMR and practice management platform allows providers to seamlessly order lab tests, capture clinical indications, and integrate results into patient records. For endocrinology, primary care, and integrative clinics, OptiMantra simplifies lab workflows, reduces administrative burden, and ensures providers can focus on delivering high-quality patient care.
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