ICD code definitions

CPT® Code 96372: Therapeutic, Prophylactic, or Diagnostic Injection (Subcutaneous or Intramuscular)

May 20, 2025
3 min read
CPT® Code 96372

Injection for therapeutic, prophylactic, or diagnostic purposes

CPT® Code 96372 is used to report the therapeutic, prophylactic, or diagnostic injection of a drug, substance, or biological agent. This code applies to subcutaneous or intramuscular injections administered in the outpatient setting or similar clinical environments. The injection is typically given as part of a treatment plan for a variety of medical conditions or for preventive measures.

When to use CPT® Code 96372

This code is appropriate when:

  • The patient receives a subcutaneous or intramuscular injection of a therapeutic, prophylactic, or diagnostic substance.
  • The drug or substance being administered does not require a complex method of administration, such as an intravenous infusion (IV).
  • The injection is given as part of a clinical procedure and is not included under other codes (for example, vaccines, allergy shots, or medications for chronic conditions).
  • The injection is a single dose of a substance, and no additional therapeutic or diagnostic injections are administered during the encounter (use CPT 96360 for additional injections in the same encounter).

Examples of substances administered under this code include vaccines, biologics, or medications like corticosteroids for inflammation or pain management.

Administration and time requirements

For CPT 96372 to be used, the following conditions must be met:

  • The injection is administered subcutaneously or intramuscularly.
  • The drug or biological substance injected is documented, along with the dosage.
  • The encounter does not include multiple injections or any additional services that would require reporting other codes (such as IV infusion or additional injections).
  • Time spent on the injection is generally less than an hour and should be recorded for accurate billing, especially in cases where multiple injection codes are used for similar services.

Key documentation tips

  • Document the injection site, such as which muscle or subcutaneous location the injection was administered to.
  • List the substance administered, including the drug name, dosage, and any relevant batch or lot numbers (especially important for biologic agents or vaccines).
  • Provide details of the patient’s response to the injection, if relevant, to support the therapeutic or prophylactic purpose.
  • Record the date and time of the injection to ensure it aligns with proper billing guidelines.

How OptiMantra supports accurate coding for CPT® 96372

OptiMantra simplifies the documentation and billing processes for procedures like CPT 96372, ensuring accurate and efficient coding. Here's how OptiMantra supports practices:

  • Automated documentation: OptiMantra prompts the provider to document essential elements such as the drug administered, dosage, and injection site, ensuring that all information required for CPT 96372 is captured.
  • Real-time coding support: The system suggests the correct codes based on entered data, such as identifying CPT 96372 for subcutaneous or intramuscular injections.
  • Time tracking features: Provides tools to track the total time spent on the encounter, making it easy to comply with coding guidelines and accurately report the services provided.
  • Comprehensive EHR templates: Optimized for injection services, these templates guide providers through the necessary steps for documenting injections and other related procedures.
  • Integrated billing and coding: OptiMantra ensures that clinical documentation is seamlessly translated into accurate billing codes, reducing the risk of errors and delays in reimbursement.
  • Audit-ready records: Keeps a detailed log of each injection administered, including patient responses, ensuring compliance with payer guidelines and minimizing audit risks.

With OptiMantra, healthcare providers can confidently code and document CPT 96372 and other injection services, leading to more accurate claims and faster reimbursements.

Try OptiMantra for free here!

Jessica Castro
Jessica Castro

Jessica is a Massachusetts-based LPN with 13+ years of experience in patient care, healthcare technology, and education. As the Implementation and Customer Success Manager at OptiMantra, she helps providers optimize EMR solutions for better workflows and patient outcomes. With a Bachelor's in Community Health and a Master's in Healthcare Innovation in progress, she is passionate about leveraging technology to improve care delivery. Through her writing, she shares insights on healthcare best practices, EHR optimization, and patient advocacy to support providers in delivering exceptional care.

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