ICD code definitions

CPT® Code 95115: Allergy Immunotherapy Injection, Single Injection

October 21, 2026
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3 min read
CPT® Code 95115

CPT® Code 95115 is used to report the professional service for administering one allergy immunotherapy injection using a provider-supplied allergenic extract. Allergy immunotherapy, commonly called allergy shots, is used to gradually reduce a patient's sensitivity to specific allergens.

This code represents the injection service and does not include the preparation or provision of the allergenic extract itself.

Key Facts About CPT® 95115

  • Service type: Allergy immunotherapy administration ‍
  • Procedure: Single allergy immunotherapy injection ‍
  • Product: Provider-provided allergenic extract ‍
  • Purpose: Administer allergen immunotherapy ‍
  • Injection count: One injection ‍
  • Provider type: Physician or qualified healthcare professional
Common clinical indications:
  • Allergic rhinitis
  • Environmental allergies
  • Sensitivity to specific inhaled allergens
  • Allergic respiratory symptoms
  • Patients undergoing an established allergy immunotherapy program

When to Use CPT® 95115

CPT 95115 may be reported when a provider administers one allergy immunotherapy injection using a provider-supplied allergenic extract.

Examples:

  • Administering a scheduled allergy shot containing a prescribed allergenic extract
  • Providing a single injection as part of an ongoing allergy immunotherapy program
  • Continuing a patient's established allergy desensitization treatment

The medical record should support the immunotherapy treatment and document the injection administered.

Documentation Requirements

Documentation supporting CPT 95115 should include:

  • Patient identifiers and date of service
  • Allergy diagnosis or clinical indication
  • Allergen extract administered
  • Injection administered
  • Dose and relevant administration details
  • Injection site, when applicable
  • Patient response and observation
  • Any adverse reaction or complication
  • Ongoing immunotherapy or follow-up plan

Clear documentation helps support the medical necessity and appropriate reporting of the immunotherapy administration service.

Reimbursement and Coding Considerations

  • CPT 95115 represents one allergy immunotherapy injection
  • It should be distinguished from codes used when multiple injections are administered
  • The professional administration service is separate from the allergenic extract itself when separately reportable
  • Coverage and reimbursement vary by payer
  • Practices should verify payer-specific requirements before submitting claims
  • Documentation should accurately reflect the number of injections administered

Accurate recording of the allergen, dose, number of injections, and patient response supports appropriate coding and billing.

How OptiMantra Supports Allergy Immunotherapy Documentation

OptiMantra helps practices document allergy treatments, injections, clinical findings, and follow-up care within the patient chart.

With OptiMantra, providers can:

  • Document allergy immunotherapy injections and clinical indications
  • Record allergen and administration details
  • Document patient response and adverse reactions
  • Use customizable chart templates for consistent treatment documentation
  • Record ongoing immunotherapy plans and follow-up care
  • Maintain organized longitudinal patient records

Keeping immunotherapy administration details within the patient chart helps providers maintain consistent documentation throughout a patient's treatment course.

Try OptiMantra for free here!

Disclaimer: CPT® codes are maintained by the American Medical Association. This guide is for informational purposes only and does not replace official coding guidelines or payer policies.

Jessica Castro
Jessica Castro

Jessica is a Massachusetts-based LPN with 13+ years of experience in patient care, healthcare technology, and education. As the Implementation and Customer Success Manager at OptiMantra, she helps providers optimize EMR solutions for better workflows and patient outcomes. With a Bachelor's in Community Health and a Master's in Healthcare Innovation in progress, she is passionate about leveraging technology to improve care delivery. Through her writing, she shares insights on healthcare best practices, EHR optimization, and patient advocacy to support providers in delivering exceptional care.