ICD code definitions

CPT® Code 86376 – Immunoassay for Infectious Agent Antibody(ies), Qualitative or Semiquantitative, Each Antigen

October 14, 2025
3 min read
CPT® Code 86376

CPT® Code: 86376
Description:
Immunoassay for the qualitative or semiquantitative detection of antibodies to infectious agents for each antigen tested. This code is used when a clinician orders laboratory testing to determine the presence of specific antibodies, indicating exposure or immune response to a pathogen.

When to Use:

  • Patient presents with symptoms suggestive of infection or immune response.
  • Screening for antibodies to infectious agents such as viruses or bacteria.
  • Monitoring patient immune status, vaccination response, or post-infection recovery.

Requirements for Billing:

  • Physician or qualified healthcare provider must order the test.
  • Documentation must include clinical indications, test results, and interpretation in the patient’s medical record.
  • Each antigen tested is billed separately if multiple antigens are assessed.

Includes:

  • Laboratory processing of specimen using immunoassay techniques.
  • Reporting of qualitative or semiquantitative results to the ordering provider.
  • Interpretation and documentation in patient chart.

OptiMantra Integration:
With OptiMantra, clinics can streamline immunoassay workflows by integrating lab orders, results, and chart notes directly into the EMR. This reduces manual entry errors, ensures compliant documentation, and allows providers to review antibody test results alongside other clinical data in one centralized system—supporting faster clinical decisions and improving patient care.

Jessica Castro
Jessica Castro

Jessica is a Massachusetts-based LPN with 13+ years of experience in patient care, healthcare technology, and education. As the Implementation and Customer Success Manager at OptiMantra, she helps providers optimize EMR solutions for better workflows and patient outcomes. With a Bachelor's in Community Health and a Master's in Healthcare Innovation in progress, she is passionate about leveraging technology to improve care delivery. Through her writing, she shares insights on healthcare best practices, EHR optimization, and patient advocacy to support providers in delivering exceptional care.