CPT® Code 82784 is used to report the measurement of individual immunoglobulin classes—IgA, IgD, IgG, or IgM—in serum or plasma. These tests evaluate a patient’s humoral immune function, helping diagnose immunodeficiency disorders, monitor autoimmune conditions, assess infection response, or guide therapy with immunoglobulin replacement. Each class of immunoglobulin tested is reported separately using this code.
This code reflects the laboratory analysis itself, performed via immunoassay or other validated quantitative methods. Interpretation and patient counseling are considered separately from the test and are not included in the code.
Key facts about CPT Code 82784
Service type: Clinical laboratory test
Provider type: Physicians, laboratories, and qualified healthcare professionals
Medical services included: Yes—quantitative measurement of a single immunoglobulin class
Specimen type: Serum or plasma
Common clinical indications:
- Evaluation of suspected primary or secondary immunodeficiencies
- Monitoring patients receiving immunoglobulin therapy
- Diagnosis and follow-up of autoimmune disorders
- Assessment of infection risk or recurrent infections
- Baseline immune function evaluation prior to immunosuppressive therapy
When to use CPT Code 82784
CPT 82784 is appropriate when:
- A serum or plasma sample is collected for immunoglobulin testing
- Each immunoglobulin class is measured separately (IgA, IgD, IgG, or IgM)
- Testing is medically necessary for diagnosis, monitoring, or treatment planning
- Results will influence clinical management, such as supplementation, immunotherapy, or further immunologic workup
Examples include evaluating IgG and IgM levels in a patient with recurrent infections or monitoring IgA in a patient with suspected autoimmune disease.
Documentation requirements
To properly support CPT 82784 billing, documentation should include:
- Patient identifiers and date of specimen collection
- Sample type (serum or plasma)
- Specific immunoglobulin class tested
- Medical indication for each test
- Methodology used (immunoassay, nephelometry, or other validated quantitative techniques)
- Results and any follow-up recommendations
Accurate documentation ensures proper reimbursement, compliance, and integration with the patient’s longitudinal health record.
Reimbursement and coding considerations
CPT 82784 is typically covered by commercial insurers, Medicare, and Medicaid when medically necessary. Key considerations:
- Each immunoglobulin class tested must be billed separately
- Interpretation or clinical counseling is not included and should be billed separately if provided
- Modifier use may be required when multiple tests are performed on the same specimen
Always check payer-specific policies for lab panels and bundling rules.
How OptiMantra supports immunoglobulin testing
OptiMantra’s integrated EMR and practice management system helps practices manage laboratory workflows efficiently, including CPT 82784 testing.
With OptiMantra, providers can:
- Automatically link immunoglobulin orders to the patient’s chart for longitudinal tracking
- Track immune function trends over time for informed clinical decisions
- Document indications and follow-up plans directly in the EMR
- Generate audit-ready, compliant billing codes for each test performed
- Integrate immunoglobulin results with the patient’s broader care plan for immune, autoimmune, or infection management
By centralizing lab documentation, tracking, and billing, OptiMantra ensures accurate records, smooth workflows, and proper reimbursement for immunoglobulin testing.
Try OptiMantra for free here!
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