ICD code definitions

CPT® Code 82627: Dehydroepiandrosterone-Sulfate (DHEA-S) Test

September 12, 2025
3 min read
CPT® Code 82627

Description:
CPT® code 82627 is used for the laboratory measurement of dehydroepiandrosterone-sulfate (DHEA-S) levels in serum. DHEA-S is an androgen produced primarily by the adrenal glands and serves as a precursor for both testosterone and estrogen. Measuring DHEA-S helps evaluate adrenal gland function, diagnose androgen excess or deficiency, and assess conditions related to hormonal imbalance.

When to Use:
The DHEA-S test is commonly ordered when evaluating patients with suspected endocrine disorders, abnormal hair growth, or menstrual irregularities. It is appropriate to use CPT 82627 for:

  • Assessing adrenal hyperplasia or adrenal tumors.
  • Evaluating hirsutism, amenorrhea, or other signs of androgen excess in women.
  • Monitoring adrenal function in cases of suspected hypopituitarism or adrenal insufficiency.
  • Investigating precocious puberty or delayed puberty.

Billing Requirements:

  • Requires a serum specimen from the patient.
  • Documentation must include the clinical reason for the test, such as symptoms of hormonal imbalance or adrenal dysfunction.
  • Report only once per encounter unless separate, medically necessary testing is performed.
  • If ordered as part of a larger hormone panel, follow panel-specific coding guidance.

Includes:

  • Laboratory analysis and quantification of DHEA-S levels in serum.
  • Reporting of results to the ordering provider for clinical interpretation and ongoing patient management.

Tips for Practice Efficiency:
Accurate hormone tracking and documentation are essential in endocrine and integrative medicine. With OptiMantra, providers can:

  • Automatically link DHEA-S lab results to patient charts for ongoing trend analysis.
  • Document clinical findings and treatment adjustments in one place.
  • Ensure precise coding and billing for endocrine lab tests, reducing administrative workload and optimizing reimbursement.

By integrating hormone testing workflows into the EMR, OptiMantra helps practices monitor adrenal health, guide hormone therapy decisions, and support comprehensive patient care with accuracy and efficiency.

Try OptiMantra for free here!

Jessica Castro
Jessica Castro

Jessica is a Massachusetts-based LPN with 13+ years of experience in patient care, healthcare technology, and education. As the Implementation and Customer Success Manager at OptiMantra, she helps providers optimize EMR solutions for better workflows and patient outcomes. With a Bachelor's in Community Health and a Master's in Healthcare Innovation in progress, she is passionate about leveraging technology to improve care delivery. Through her writing, she shares insights on healthcare best practices, EHR optimization, and patient advocacy to support providers in delivering exceptional care.