Overview
CPT® code 82533 is used to report a laboratory test that measures total cortisol levels in a patient’s serum. Cortisol is a steroid hormone produced by the adrenal glands and plays a critical role in regulating metabolism, stress response, and immune function. Measuring total cortisol helps clinicians evaluate adrenal gland health and diagnose conditions such as adrenal insufficiency (Addison’s disease) or hypercortisolism (Cushing’s syndrome).
When to Use CPT 82533
Use CPT 82533 when assessing adrenal function or suspected hormone imbalance. It is appropriate for patients presenting with symptoms such as unexplained fatigue, weight changes, low blood pressure, or abnormal glucose levels. The test is also useful for evaluating stress response or monitoring corticosteroid therapy.
Key Requirements
- Requires a serum specimen for analysis.
- The test may be performed at specific times of day (typically morning) due to natural cortisol fluctuations.
- Often ordered with ACTH testing (82024) for comprehensive adrenal assessment.
- Documentation should specify the clinical indication, timing of sample collection, and any relevant medications that may affect cortisol levels.
Billing Guidelines
- Report 82533 for quantitative measurement of total cortisol in serum.
- Do not report this code with 82530 (Cortisol, free) for the same specimen.
- Ensure medical necessity is documented, including symptoms or suspected endocrine disorders.
- Repeat testing should be clearly justified if multiple samples are collected for diurnal or stimulation testing.
Example Clinical Scenarios
- A patient with persistent fatigue and hypotension is evaluated for adrenal insufficiency using total cortisol testing.
- A provider monitors cortisol levels in a patient undergoing steroid taper therapy to assess adrenal recovery.
- A patient with obesity and hypertension is tested for Cushing’s syndrome using morning cortisol measurement.
Summary
CPT® code 82533 identifies laboratory analysis of total cortisol, a key hormone for assessing adrenal and metabolic health. Measuring cortisol levels provides valuable diagnostic insight into hormonal balance, stress regulation, and endocrine function—helping guide targeted treatment strategies.
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