ICD code definitions

CPT® Code 99000: Handling and/or Conveyance of Specimens for Laboratory

September 11, 2025
3 min read
CPT® Code 99000

CPT® code 99000 is used to report the handling and/or conveyance of a patient specimen to a laboratory. This code applies when specimens, such as blood, urine, or tissue samples, are collected in a clinical setting and sent to an off-site laboratory for analysis. It ensures proper documentation and billing for specimen handling services, which are distinct from the laboratory testing itself.

When to Use CPT® Code 99000

  • When a provider or clinical staff collects a patient specimen and prepares it for transport to a laboratory.
  • For specimens including blood, urine, tissue, swabs, or other biological samples.
  • When the handling or conveyance of the specimen is medically necessary and documented.
  • Only one claim is billed per day for the same type of specimen handling.

Billing Requirements

  • Report per collection day, not per individual specimen, unless multiple types require separate handling.
  • Documentation should include date of collection, specimen type, handling procedures, and laboratory destination.
  • Often used in combination with CPT® codes for laboratory tests, but does not include the actual test itself.
  • Verify payer policies, as some insurers may consider specimen handling included in lab fees.

Common Clinical Scenarios

  • A nurse collects a blood sample and prepares it for shipment to an external lab for analysis.
  • A clinic sends a urine sample to a reference lab for culture and sensitivity testing.
  • A primary care office collects multiple tissue swabs and conveys them to a pathology lab.

Simplify Specimen Documentation with OptiMantra

Accurate documentation and billing for CPT® 99000 ensures compliance and supports proper reimbursement for specimen handling services. OptiMantra’s EMR and practice management platform makes it easy to log specimen collection details, track sample transport, and integrate with laboratory orders. Clinics, wellness centers, and integrative practices can streamline workflows, reduce errors, and focus on high-quality patient care.

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Jessica Castro
Jessica Castro

Jessica is a Massachusetts-based LPN with 13+ years of experience in patient care, healthcare technology, and education. As the Implementation and Customer Success Manager at OptiMantra, she helps providers optimize EMR solutions for better workflows and patient outcomes. With a Bachelor's in Community Health and a Master's in Healthcare Innovation in progress, she is passionate about leveraging technology to improve care delivery. Through her writing, she shares insights on healthcare best practices, EHR optimization, and patient advocacy to support providers in delivering exceptional care.