Tesofensine
Tesofensine a triple reuptake inhibitor serotonin-noradrenaline-dopamine reuptake inhibitors (SNDRI) which was intially designed to treat neurological disorders such as Parkinson’s disease and Alzheimer's disease, however it showed limited efficacy on neurogenic disorders and the drug was then orphaned.
How it works?By inhibiting the reuptake of these neurotransmitters, there’s more concentration of these neurotransmitters causing several physiological and psychological effects:
- Serotonin: An increase in serotonin levels can contribute to an improved mood and a sense of well-being. This may help individuals using Tesofensine experience enhanced emotional stability and potentially reduce emotional eating
- Noradrenaline: Increased noradrenaline levels can stimulate the “fight” or “flight” response in the body, which can lead to increased alertness and energy expenditure. This effect may help boost metabolic rate and calorie burning
- Dopamine: Dopamine is a key neurotransmitter involved in the rewards and pleasure pathways of the brain. By increasing dopamine levels, Tesofensine may lead to a reduced sense of craving and reward-driven eating behaviour.
Potential Side effectsDry mouth, headache, nausea, insomnia, increased heart rate, increased blood pressure.
In summary, Tesofensine’s mechanism of action centers on its ability to modulate these neurotransmitter systems in the brain. By inhibiting the reuptake of serotonin, noradrenaline and dopamine, it can influence mood, appetite regulation and energy balance.
This ultimately results in a feeling of fullness, reduced cravings and enhanced satiety, making it a proposed option for weight management.